The bowler suffered shoulder injury during the second Test against New Zealand.
He also missed the series decider against the Kiwis — which Pakistan lost by 123 runs earlier this month.
Mohammad Amir — who was sidelined after below-par performance in the Asia Cup — is set to replace the injured pacer.
He is expected to feature alongside fellow pacers Shaheen Shah Afridi — who made his debut against New Zealand in the recently concluded Test series in UAE - and Hasan Ali.
Meanwhile, the opening slot, which was vacant after the retirement of veteran all-rounder Mohammad Hafeez, will now be filled by returning left-hander Fakhar Zaman.
Zaman missed series against the Blackcaps after sustaining knee injury during second Test against Australia.
He had made his Test debut in the same game and scored 94 and 66 in first and second innings respectively.
Opener Imamul Haq — who scored only 74 runs in his last three Tests — showed some form with the bat in the tour game.
The left-handed batsman scored a promising 66 in the second innings to help Pakistan win the game.
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