Pictures from the crash scene show victims strewn across the road next to the overturned truck. There were also rows of what appeared to be bodies covered in white sheets.
It is one of the worst accidents of its kind in Mexico. Forty-nine people were confirmed dead at the scene and five more died in hospital, Chiapas Governor Rutilio Escandón said.
He said that 83 men and 22 women were injured in the crash.
Emergency officials said the victims included men, women and children. Their nationalities have not been confirmed, but local officials said most of the people on board were from Honduras and Guatemala.
The truck was reportedly speeding when it flipped on a sharp bend and hit a pedestrian bridge on a main road leading to the Chiapas state capital Tuxtla Gutiérrez.
Chiapas, which neighbours Guatamala, is a major transit point for undocumented migrants.
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