Babar top-scored with 68 in Pakistan s stumps total of 350 for eight -- a lead of 166 runs after they bowled England out for 184 in their first innings.
But he was forced to retire hurt before the close after being struck a painful blow on the wrist by England pace bowling all-rounder Ben Stokes.
The 23-year-old Babar, for whom this was indeed an unlucky 13th Test, received sympathetic applause from a large crowd as he walked off after several minutes of on-field treatment
Babar was taken to a hospital for a scan which confirmed he would not be able to get back on the field at Lord s or indeed take part in next week s second Test at Headingley.
"We took him for a precautionary X-ray which unfortunately confirmed a fractured left wrist," said Pakistan physiotherapist Cliff Deacon.
"It normally takes four to six weeks to heal so we will assess him with further X-rays."
The Pakistan Cricket Board added it had no intention to add a replacement batsman to the tour squad.
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